研究業績

Ⅱ. 英文原著論文及びレビュー

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  • 190) Kamiyama N, Ueno M, Sasaki Y, Chalalai T, Sachi N, Ozaka S, Soga Y, Kagoshima Y, Ekronarongchai S, Okamoto M, Yamamoto M, Kobayashi T.CCR2-dependent placental migration of inflammatory monocytes suppresses abnormal pregnancies caused by Toxoplasma gondii infection. Int Immunol. (2024) Jul 25:dxae046. doi: 10.1093/intimm/dxae046. PMID: 39051675

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    189) Tachibana Y, Sasai M, Yamamoto M (Corresponding author). CRISPR screens identify genes essential for in vivo virulence among proteins of hyperLOPIT-unassigned subcellular localization in Toxoplasma. mBio (2024) Jul 31:e0172824. doi: 10.1128/mbio.01728-24. PMID: 39082802

    188) Tsogtsaikhan S, Inoue SI, Bayarsaikhan G, Macalinao ML, Kimura D, Miyakoda M, Yamamoto M, Hara H, Yoshida H, Yui K. Regulation of memory CD4+ T cell generation by intrinsic and extrinsic IL-27 signaling during malaria infection. Int Immunol. (2024) Jun 19:dxae039. doi: 10.1093/intimm/dxae039.

     

  • 187) Ihara F, Kyan H, Takashima Y, Ono F, Hayashi K, Matsuo T, Igarashi M, Nishikawa Y, Hikosaka K, Sakamoto H, Nakamura S, Motooka D, Yamauchi K, Ichikawa-Seki M, Fukumoto S, Sasaki M, Ikadai H, Kusakisako K, Ohari Y, Yoshida A, Sasai M, Grigg ME, Yamamoto M (Corresponding author).  Far-East Asian Toxoplasma isolates share ancestry with North and South/Central American recombinant lineages. Nat Commun. (2024) 15:4278. doi: 10.1038/s41467-024-47625-6.

  • 186) Sakuma C, Shizukuishi S, Ogawa M, Honjo Y, Takeyama H, Guan JL, Weiser J, Sasai M, Yamamoto M, Ohnishi M, Akeda Y.Individual Atg8 paralogs and a bacterial metabolite sequentially promote hierarchical CASM-xenophagy induction and transition. Cell Rep. (2024) 43:114131. doi: 10.1016/j.celrep.2024.114131.

  • 185) Temizoz B, Shibahara T, Hioki K, Hayashi T, Kobiyama K, Lee MSJ, Surucu N, Sag E, Kumanogoh A, Yamamoto M, Gursel M, Ozen S, Kuroda E, Coban C, Ishii KJ. 5,6-dimethylxanthenone-4-acetic acid (DMXAA), a partial STING agonist, competes for human STING activation. Front Immunol. 15:1353336. (2024) doi: 10.3389/fimmu.2024.1353336.

  • 184)  Okamoto M, Yamamoto M (Corresponding author). TCR Signals Controlling Adaptive Immunity against Toxoplasma and Cancer. Adv Exp Med Biol.1444:177-193. (2024)  doi: 10.1007/978-981-99-9781-7_12.

  • 183)  Ihara F, Yamamoto M (Corresponding author). The role of IFN-γ-mediated host immune responses in monitoring and the elimination of Toxoplasma gondii infection. Int Immunol. 36:199-210.(2024) doi: 10.1093/intimm/dxae001.

  • 182) Okuma H, Saijo-Hamano Y, Yamada H, Sherif AA, Hashizaki E, Sakai N, Kato T, Imasaki T, Kikkawa S, Nitta E, Sasai M, Abe T, Sugihara F, Maniwa Y, Kosako H, Takei K, Standley DM, Yamamoto M, Nitta R. Structural basis of Irgb6 inactivation by Toxoplasma gondii through the phosphorylation of switch I. Genes Cells. 29:17-38. (2024) doi: 10.1111/gtc.13080.

  • 181) Maeda R, Seki N, Uwamino Y, Wakui M, Nakagama Y, Kido Y, Sasai M, Taira S, Toriu N, Yamamoto M, Matsuura Y, Uchiyama J, Yamaguchi G, Hirakawa M, Kim YG, Mishima M, Yanagita M, Suematsu M, Sugiura Y. Amino acid catabolite markers for early prognostication of pneumonia in patients with COVID-19. Nat Commun. 4:8469. (2023) doi: 10.1038/s41467-023-44266-z.

  • 180) Fisch D, Pfleiderer MM, Anastasakou E, Mackie GM, Wendt F, Liu X, Clough B, Lara-Reyna S, Encheva V, Snijders AP, Bando H, Yamamoto M, Beggs AD, Mercer J, Shenoy AR, Wollscheid B, Maslowski KM, Galej WP, Frickel EM. PIM1 controls GBP1 activity to limit self-damage and to guard against pathogen infection. Science. (2023) 382:eadg2253. doi: 10.1126/science.adg2253. PMID: 37797010

  • 179) Yamada K, Tazaki A, Ushio-Watanabe N, Usui Y, Takeda A, Matsunaga M, Suzumura A, Shimizu H, Zheng H, Ariefta NR, Yamamoto M, Hara H, Goto H, Sonoda KH, Nishiguchi KM, Kato M, Nishikawa Y, Toyokuni S, Kaneko H. Retinal ferroptosis as a critical mechanism for the induction of retinochoroiditis during ocular toxoplasmosis. Redox Biol. (2023) 67:102890. doi: 10.1016/j.redox.2023.102890. PMID: 37738924

  • 178) Boonyaleka K, Okano T, Iida T, Leewananthawet A, Sasai M, Yamamoto M, Ashida H, Suzuki T. Fusobacterium nucleatum infection activates the noncanonical inflammasome and exacerbates inflammatory response in DSS-induced colitis. Eur J Immunol. (2023) Jul 20:e2350455. doi: 10.1002/eji.202350455.

  • 177) Okamoto M, Sasai M, Kuratani A, Okuzaki D, Arai M, Wing JB, Sakaguchi S, Yamamoto M (Corresponding author). A genetic method specifically delineates Th1-type Treg cells and their roles in tumor immunity. Cell Rep. (2023) 42:112813. doi: 10.1016/j.celrep.2023.112813.

  • 176) Tachibana Y, Hashizaki E, Sasai M, Yamamoto M (Corresponding author). Host genetics highlights IFN-γ-dependent Toxoplasma genes encoding secreted and non-secreted virulence factors in in vivo CRISPR screens. Cell Rep. (2023) 42:e112592.

  • 175) Enosi Tuipulotu D, Feng S, Pandey A, Zhao A, Ngo C, Mathur A, Lee J, Shen C, Fox D, Xue Y, Kay C, Kirkby M, Lo Pilato J, Kaakoush NO, Webb D, Rug M, Robertson AA, Tessema MB, Pang S, Degrandi D, Pfeffer K, Augustyniak D, Blumenthal A, Miosge LA, Brüstle A, Yamamoto M, Reading PC, Burgio G, Man SM. Immunity against Moraxella catarrhalis requires guanylate-binding proteins and caspase-11-NLRP3 inflammasomes. EMBO J. (2023) 42:e112558. 

  • 174) Singh S, Murillo-León M, Endres NS, Arenas Soto AF, Gómez-Marín JE, Melbert F, Kanneganti TD, Yamamoto M, Campos C, Howard JC, Taylor GA, Steinfeldt T. ROP39 is an Irgb10-specific parasite effector that modulates acute Toxoplasma gondii virulence. PLoS Pathog. (2023) 19:e1011003. 

  • 173) Hashizaki E, Sasai M, Okuzaki D, Nishi T, Kobayashi T, Iwanaga S, Yamamoto M (Corresponding author). Toxoplasma IWS1 Determines Fitness in Interferon-γ-Activated Host Cells and Mice by Indirectly Regulating ROP18 mRNA Expression.
    mBio. (2023) Jan 30:e0325622. doi: 10.1128/mbio.03256-22. Online ahead of print. PMID: 36715543     

  • 172) Nakamura J, Yamamoto T, Takabatake Y, Namba-Hamano T, Minami S, Takahashi A, Matsuda J, Sakai S, Yonishi H, Maeda S, Matsui S, Matsui I, Hamano T, Takahashi M, Goto M, Izumi Y, Bamba T, Sasai M, Yamamoto M, Matsusaka T, Niimura F, Yanagita M, Nakamura S, Yoshimori T, Ballabio A, Isaka Y.  TFEB-mediated lysosomal exocytosis alleviates high fat diet-induced lipotoxicity in the kidney.
    JCI Insight. (2023) Jan 17:e162498. doi: 10.1172/jci.insight.162498. Online ahead of print.PMID: 36649084 

  • 171) Singh S, Murillo-León M, Endres NS, Arenas Soto AF, Gómez-Marín JE, Melbert F, Kanneganti TD, Yamamoto M, Campos C, Howard JC, Taylor GA, Steinfeldt T. ROP39 is an Irgb10-specific parasite effector that modulates acute Toxoplasma gondii virulence.
    PLoS Pathog. (2023) Jan 5;19(1):e1011003. doi: 10.1371/journal.ppat.1011003. eCollection 2023 Jan.    PMID: 36603017 

  • 170) Kohl L, Siddique MNAA, Bodendorfer B, Berger R, Preikschat A, Daniel C, Ölke M, Liebler-Tenorio E, Schulze-Luehrmann J, Mauermeir M, Yang KT, Hayek I, Szperlinski M, Andrack J, Schleicher U, Bozec A, Krönke G, Murray PJ, Wirtz S, Yamamoto M, Schatz V, Jantsch J, Oefner P, Degrandi D, Pfeffer K, Mertens-Scholz K, Rauber S, Bogdan C, Dettmer K, Lührmann A, Lang R. Macrophages inhibit Coxiella burnetii by the ACOD1-itaconate pathway for containment of Q fever.
    EMBO Mol Med. (2022) Dec 7:e15931. doi: 10.15252/emmm.202215931. Online ahead of print.    PMID: 36479617

  • 169) Hayashi H, Sun J, Yanagida Y, Otera T, Sasai M, Chang CY, Tai JA, Nishikawa T, Yamashita K, Sakaguchi N, Yoshida S, Baba S, Shimamura M, Okamoto S, Amaishi Y, Chono H, Mineno J, Rakugi H, Morishita R, Yamamoto M, Nakagami H. Modified DNA vaccine confers improved humoral immune response and effective virus protection against SARS-CoV-2 delta variant.
    Sci Rep. (2022) Dec 3;12(1):20923. doi: 10.1038/s41598-022-24519-5.PMID: 36463322     

  • 168) Yamada H, Abe T, Nagaoka H, Takashima E, Nitta R, Yamamoto M, Takei K. Recruitment of Irgb6 to the membrane is a direct trigger for membrane deformation.
    Front Cell Infect Microbiol. (2022) Sep 9;12:992198. doi: 10.3389/fcimb.2022.992198. eCollection 2022.    PMID: 36159643 

  • 167) Nishikawa T, Chang CY, Tai JA, Hayashi H, Sun J, Torii S, Ono C, Matsuura Y, Ide R, Mineno J, Sasai M, Yamamoto M, Nakagami H, Yamashita K .  Immune response induced in rodents by anti-CoVid19 plasmid DNA vaccine via pyro-drive jet injector inoculation.
    Immunol Med. (2022) Dec;45(4):251-264. doi: 10.1080/25785826.2022.2111905. Epub 2022 Aug 24.PMID: 36001011

  • 166) Feng S, Enosi Tuipulotu D, Pandey A, Jing W, Shen C, Ngo C, Tessema MB, Li FJ, Fox D, Mathur A, Zhao A, Wang R, Pfeffer K, Degrandi D, Yamamoto M, Reading PC, Burgio G, Man SM. Pathogen-selective killing by guanylate-binding proteins as a molecular mechanism leading to inflammasome signaling.
    Nat Commun. (2022) Jul 29;13(1):4395. doi: 10.1038/s41467-022-32127-0.PMID: 35906252

  • 165) Sasai M, Yamamoto M (Corresponding author).  Anti-Toxoplasma host defense systems and the parasitic counterdefense mechanisms.
    Parasitol Int. (2022) Aug;89:102593. doi: 10.1016/j.parint.2022.102593. Epub 2022 Apr 29.PMID: 35500831 

  • 164) Gullicksrud JA, Sateriale A, Engiles JB, Gibson AR, Shaw S, Hutchins ZA, Martin L, Christian DA, Taylor GA, Yamamoto M, Beiting DP, Striepen B, Hunter CA. Enterocyte-innate lymphoid cell crosstalk drives early IFN-γ-mediated control of Cryptosporidium.
    Mucosal Immunol. (2022) Feb;15(2):362-372. doi: 10.1038/s41385-021-00468-6. Epub 2021 Nov 8.PMID: 34750455 

  • 163) Christgen S, Place DE, Zheng M, Briard B, Yamamoto M, Kanneganti TD. The IFN-inducible GTPase IRGB10 regulates viral replication and inflammasome activation during influenza A virus infection in mice.
    Eur J Immunol. (2022) Feb;52(2):285-296. doi: 10.1002/eji.202149305. Epub 2021 Nov 9.PMID: 34694641 

  • 162) Yang C, Lei L, Collins JWM, Briones M, Ma L, Sturdevant GL, Su H, Kashyap AK, Dorward D, Bock KW, Moore IN, Bonner C, Chen CY, Martens CA, Ricklefs S, Yamamoto M, Takeda K, Iwakura Y, McClarty G, Caldwell HD. Chlamydia evasion of neutrophil host defense results in NLRP3 dependent myeloid-mediated sterile inflammation through the purinergic P2X7 receptor.
    Nat Commun. (2021) Sep 15;12(1):5454. doi: 10.1038/s41467-021-25749-3.PMID: 34526512 

  • 161) Hijikata M, Morioka I, Okahashi A, Nagano N, Kawakami K, Komatsu A, Kawana K, Ohyama S, Fujioka K, Tanimura K, Deguchi M, Sasai M, Yamamoto M, Yamada H. A prospective cohort study of newborns born to mothers with serum Toxoplasma gondii immunoglobulin M positivity during pregnancy.
    J Infect Chemother. S1341-321X, 2021

  • 160) Liu Y, Soh WT, Kishikawa JI, Hirose M, Nakayama EE, Li S, Sasai M, Suzuki T, Tada A, Arakawa A, Matsuoka S, Akamatsu K, Matsuda M, Ono C, Torii S, Kishida K, Jin H, Nakai W, Arase N, Nakagawa A, Matsumoto M, Nakazaki Y, Shindo Y, Kohyama M, Tomii K, Ohmura K, Ohshima S, Okamoto T, Yamamoto M, Nakagami H, Matsuura Y, Nakagawa A, Kato T, Okada M, Standley DM, Shioda T, Arase H. An infectivity-enhancing site on the SARS-CoV-2 spike protein targeted by antibodies.
    Cell (2021) 184:3452-3466

  • 159) Wang ZJ, Yu SM, Gao JM, Zhang P, Hide G, Yamamoto M, Lai DH, Lun ZR. High resistance to Toxoplasma gondii infection in inducible nitric oxide synthase knockout rats.
    iScience. (2021) 24:103280

  • 158) Nyonda MA, Hammoudi PM, Ye S, Maire J, Marq JB, Yamamoto M, Soldati-Favre D. Toxoplasma gondii GRA60 is an effector protein that modulates host cell autonomous immunity and contributes to virulence.
    Cell Microbiol. (2021) 23:e13278

  • 157) Saijo-Hamano Y, Sherif AA, Pradipta A, Sasai M, Sakai N, Sakihama Y, Yamamoto M, Standley DM, Nitta R. Structural basis of membrane recognition of Toxoplasma gondii vacuole by Irgb6.
    Life Sci Alliance. (2021) 5:e202101149

  • 156) Pradipta A, Sasai M, Motani K, Ma JS, Lee Y, Kosako H, Yamamoto M (Corresponding author).Cell-autonomous Toxoplasma killing program requires Irgm2 but not its microbe vacuolar localization.
    Life Sci Alliance. (2021) Jun 2;4(7):e202000960. doi: 10.26508/lsa.202000960.  PMID: 34078740

  • 155)  Hirano J, Yoshio S, Sakai Y, Songling L, Suzuki T, Itoh Y, Zhang H, Chen DV, Haga S, Oomori H, Kodama T, Maeda Y, Ono Y, Takahashi Y, Standley DM, Yamamoto M, Moriishi K, Moriya K, Kanto T, Takehara T, Koike K, Matsuura Y, Okamoto T. Hepatitis C virus modulates signal peptide peptidase to alter host protein processing.
    PNAS. 2021 Jun 1;118(22):e2026184118. doi: 10.1073/pnas.2026184118.PMID: 34035171 

  • 154) Sasai M, Ma JS, Okamoto M, Nishino K, Nagaoka H, Takashima E, Pradipta A, Lee Y, Kosako H, Suh PG, Yamamoto M (Corresponding author). Uncovering a novel role of PLCβ4 in selectively mediating TCR signaling in CD8+ but not CD4+ T cells.
    J Exp Med. (2021). Jul 5;218(7):e20201763. doi: 10.1084/jem.20201763. PMID: 33970189

  • 153) Pradipta A, Bando H, Ma JS, Tanaka S, Sasai M, Yamamoto M (Corresponding author). Plasmodium UIS3 avoids host cell-autonomous exclusion that requires GABARAPs but not LC3 and autophagy.
    Parasitol Int. (2021) Mar 23;83:102335. doi: 10.1016/j.parint.2021.102335. 

  • 152) Place DE, Malireddi RKS, Kim J, Vogel P, Yamamoto M, Kanneganti TD. Osteoclast fusion and bone loss are restricted by interferon inducible guanylate binding proteins.
    Nat Commun. (2021) Jan 21;12(1):496. doi: 10.1038/s41467-020-20807-8.PMID: 33479228

  • 151) Kim S, Lee JY, Shin SG, Kim JK, Silwal P, Kim YJ, Shin NR, Kim PS, Won M, Lee SH, Kim SY, Sasai M, Yamamoto M, Kim JM, Bae JW, Jo EK. ESRRA (estrogen related receptor alpha) is a critical regulator of intestinal homeostasis through activation of autophagic flux via gut microbiota.
    Autophagy. (2020) Dec 15:1-20. doi: 10.1080/15548627.2020.1847460. Online ahead of print.PMID: 33172329

    150) Mohammadi N, Lindgren H, Golovliov I, Eneslätt K, Yamamoto M, Martin A, Henry T, Sjöstedt A.  Guanylate-Binding Proteins Are Critical for Effective Control of Francisella tularensis Strains in a Mouse Co-Culture System of Adaptive Immunity.
    Front Cell Infect Microbiol.     (2020) Dec 10;10:594063. doi: 10.3389/fcimb.2020.594063. eCollection 2020.PMID: 33363054 

    149) Haldar AK, Nigam U, Yamamoto M, Coers J, Goyal N. Guanylate Binding Proteins Restrict Leishmania donovani Growth in Nonphagocytic Cells Independent of Parasitophorous Vacuolar Targeting.
    mBio. (2020) Jul 28;11(4):e01464-20. doi: 10.1128/mBio.01464-20.PMID: 32723921

    148) Eren E, Planès R, Bagayoko S, Bordignon PJ, Chaoui K, Hessel A, Santoni K, Pinilla M, Lagrange B, Burlet-Schiltz O, Howard JC, Henry T, Yamamoto M, Meunier E. Irgm2 and Gate-16 cooperatively dampen Gram-negative bacteria-induced caspase-11 response.
    EMBO Rep. (2020) Nov 5;21(11):e50829. doi: 10.15252/embr.202050829. Epub 2020 Oct 30. PMID: 33124769

  • 147) Nakamura S, Shigeyama S, Minami S, Shima T, Akayama S, Matsuda T, Esposito A, Napolitano G, Kuma A, Namba-Hamano T, Nakamura J, Yamamoto K, Sasai M, Tokumura A, Miyamoto M, Oe Y, Fujita T, Terawaki S, Takahashi A, Hamasaki M, Yamamoto M, Okada Y, Komatsu M, Nagai T, Takabatake Y, Xu H, Isaka Y, Ballabio A, Yoshimori T.  LC3 lipidation is essential for TFEB activation during the lysosomal damage response to kidney injury.
    Nat Cell Biol. (2020) Oct;22(10):1252-1263. doi: 10.1038/s41556-020-00583-9. Epub 2020 Sep 28.PMID: 32989250

  • 146) Sakaguchi N, Sasai M, Bando H, Lee Y, Pradipta A, Ma JS, Yamamoto M.Role of Gate-16 and Gabarap in Prevention of Caspase-11-Dependent Excess Inflammation and Lethal Endotoxic Shock.
    Front Immunol. (2020) Sep 15;11:561948. doi: 10.3389/fimmu.2020.561948. eCollection 2020.PMID: 33042141 

  • 145) Nyonda MA, Hammoudi PM, Ye S, Maire J, Marq JB, Yamamoto M, Soldati-Favre D. Toxoplasma gondii GRA60 is an effector protein that modulates host cell autonomous immunity and contributes to virulence.
    Cell Microbiol. (2020) Oct 11:e13278. doi: 10.1111/cmi.13278. Online ahead of print. PMID: 33040458

  • 144) Kongsomboonvech AK, Rodriguez F, Diep AL, Justice BM, Castallanos BE, Camejo A, Mukhopadhyay D, Taylor GA, Yamamoto M, Saeij JPJ, Reese ML, Jensen KDC. Naïve CD8 T cell IFNγ responses to a vacuolar antigen are regulated by an inflammasome-independent NLRP3 pathway and Toxoplasma gondii ROP5.
    PLoS Pathog. (2020) Aug 27;16(8):e1008327. doi: 10.1371/journal.ppat.1008327. eCollection 2020 Aug.PMID: 32853276 

  • 143) Ihara F, Fereig RM, Himori Y, Kameyama K, Umeda K, Tanaka S, Ikeda R, Yamamoto M, Nishikawa Y. Toxoplasma gondii Dense Granule Proteins 7, 14, and 15 Are Involved in Modification and Control of the Immune Response Mediated via NF-κB Pathway.
    Front Immunol. (2020) Jul 31;11:1709. doi: 10.3389/fimmu.2020.01709. eCollection 2020.PMID: 32849602 

  • 142) Fisch D, Clough B, Domart MC, Encheva V, Bando H, Snijders AP, Collinson LM, Yamamoto M, Shenoy AR, Frickel EM.Human GBP1 Differentially Targets Salmonella and Toxoplasma to License Recognition of Microbial Ligands and Caspase-Mediated Death.
    Cell Rep. (2020) Aug 11;32(6):108008. doi: 10.1016/j.celrep.2020.108008.PMID: 32783936 

  • 141) Haldar AK, Nigam U, Yamamoto M, Coers J, Goyal N. Guanylate Binding Proteins Restrict Leishmania donovani Growth in Nonphagocytic Cells Independent of Parasitophorous Vacuolar Targeting.
    mBio. (2020) Jul 28;11(4):e01464-20. doi: 10.1128/mBio.01464-20.mBio. 2020. PMID: 32723921

  • 140) Place DE, Briard B, Samir P, Karki R, Bhattacharya A, Guy CS, Peters JL, Frase S, Vogel P, Neale G, Yamamoto M, Kanneganti TD.Interferon inducible GBPs restrict Burkholderia thailandensis motility induced cell-cell fusion.
    PLoS Pathog. (2020) Mar 9;16(3):e1008364. doi: 10.1371/journal.ppat.1008364. eCollection 2020 Mar.PLoS Pathog. 2020. PMID: 32150572

  • 139) Sasai M, Yamamoto M (Corresponding author). Decision by injection without infection.
    J Exp Med. (2020) 217. doi: 10.1084/jem.20192145. Review.

  • 138) Nishiyama S, Pradipta A, Ma JS, Sasai M, Yamamoto M (Corresponding author). T cell-derived interferon-γ is required for host defense to Toxoplasma gondii.　
    Parasitol Int. (2020) 75:102049. doi: 10.1016/j.parint.2019.102049.
  • 137) Lee Y, Yamada H, Pradipta A, Ma JS, Okamoto M, Nagaoka H, Takashima E, Standley DM, Sasai M, Takei K, Yamamoto M (Corresponding author).
    Initial phospholipid-dependent Irgb6 targeting to Toxoplasma gondii vacuoles mediates host defense.
    Life Sci. Alliance. (    2019) Dec 18;3(1).. doi: 10.26508/lsa.201900549.
  •  136) Sasai M, Yamamoto M (Corresponding author).
    Innate, adaptive, and cell-autonomous immunity against Toxoplasma gondii infection.
    Exp Mol Med.     (2019) Dec 11;51(12):156. doi: 10.1038/s12276-019-0353-9. Review
  • 135) Fisch D, Bando H, Clough B, Hornung V, Yamamoto M, Shenoy AR, Frickel EM.
    Human GBP1 is a microbe-specific gatekeeper of macrophage apoptosis and pyroptosis.
    EMBO J. (2019) Jul 1;38(13):e100926. doi: 10.15252/embj.2018100926.
  • 134) Bando H, Pradipta A, Iwanaga S, Okamoto T, Okuzaki D, Tanaka S, Vega-Rodríguez J, Lee Y, Ma JS, Sakaguchi N, Soga A, Fukumoto S, Sasai M, Matsuura Y, Yuda M, Jacobs-Lorena M, Yamamoto M (Corresponding author).
    CXCR4 regulates Plasmodium development in mouse and human hepatocytes.
    J Exp Med. (2019)     Aug 5;216(8):1733-1748.  doi: 10.1084/jem.20182227.
  • 133) Bando H, Lee Y, Sakaguchi N, Pradipta A, Sakamoto R, Tanaka S, Ma JS, Sasai M, Yamamoto M (Corresponding author).
    Toxoplasma effector GRA15-dependent suppression of IFN-γ-induced antiparasitic response in human neurons.
    Front. Cell. Infect. Microbiol. (2019) May 1;9:140. doi: 10.3389/fcimb.2019.00140.
  • 132) Orimo T, Sasaki I, Hemmi H, Ozasa T, Fukuda-Ohta Y, Ohta T, Morinaka M, Kitauchi M, Yamaguchi T, Sato Y, Tanaka T, Hoshino K, Katayama KI, Fukuda S, Miyake K, Yamamoto M, Satoh T, Furukawa K, Kuroda E, Ishii KJ, Takeda K, Kaisho T. Cholera toxin B induces interleukine-1β production from resident peritoneal macrophages through pyrin as well as NLRP3 inflammasome.
    Int Immunol. (2019)     Oct; 31(10): 657–668. Published online 2019 Jan 25. doi: 10.1093/intimm/dxz004
  • 131) Briard B, Karki R, Malireddi RKS, Bhattacharya A, Place DE, Mavuluri J, Peters JL, Vogel P, Yamamoto M, Kanneganti TD. Fungal ligands released by innate immune effectors promote inflammasome activation during Aspergillus fumigatus infection.
    Nat Microbiol. (2019) Feb;4(2):316-327. doi: 10.1038/s41564-018-0298-0. PMID:30510167
  • 129) Kim JK, Kim YS, Lee HM, Jin HS, Neupane C, Kim S, Lee SH, Min JJ, Sasai M, Jeong JH, Choe SK, Kim JM, Yamamoto M, Choy HE, Park JB, Jo EK.
    GABAergic signaling linked to autophagy enhances host protection against intracellular bacterial infections.
    Nat Commun. (2018) Oct 10;9(1):4184. doi: 10.1038/s41467-018-06487-5.
  • 128) Bando H, Lee Y, Sakaguchi N, Pradipta A, Ma JS, Tanaka S, Cai Y, Liu J, Shen J, Nishikawa Y, Sasai M, Yamamoto M (Corresponding author).
    Inducible Nitric Oxide Synthase Is a Key Host Factor for Toxoplasma GRA15-Dependent Disruption of the Gamma Interferon-Induced Antiparasitic Human Response.
    MBio. 2018 Oct 9;9(5). pii: e01738-18. doi: 10.1128/mBio.01738-18.
  • 127) Bando H, Sakaguchi N, Lee Y, Pradipta A, Ma JS, Tanaka S, Lai DH, Liu J, Lun ZR, Nishikawa Y, Sasai M, Yamamoto M (Corresponding author).
    Toxoplasma Effector TgIST Targets Host IDO1 to Antagonize the IFN-γ-Induced Anti-parasitic Response in Human Cells.
    Front Immunol. (2018) 9:2073. doi: 10.3389/fimmu.2018.02073.
  • 126) Ingram JP, Tursi S, Zhang T, Guo W, Yin C, A Wynosky-Dolfi M, van der Heijden J, Cai KQ, Yamamoto M, Finlay BB, Brodsky IE, Grivennikov SI, Tükel Ç, Balachandran S.
    A Nonpyroptotic IFN-γ-Triggered Cell Death Mechanism in Nonphagocytic Cells Promotes Salmonella Clearance In Vivo.
    J Immunol. 2018 May 15;200(10):3626-3634. doi: 10.4049/jimmunol.1701386.
  • 125) Liu BC, Sarhan J, Panda A, Muendlein HI, Ilyukha V, Coers J, Yamamoto M, Isberg RR, Poltorak A.
    Constitutive Interferon Maintains GBP Expression Required for Release of Bacterial Components Upstream of Pyroptosis and Anti-DNA Responses.
    Cell Rep. 2018 Jul 3;24(1):155-168.e5. doi: 10.1016/j.celrep.2018.06.012.
  • 124) Balakrishnan A, Karki R, Berwin B, Yamamoto M, Kanneganti TD.
    Guanylate binding proteins facilitate caspase-11-dependent pyroptosis in response to type 3 secretion system-negative Pseudomonas aeruginosa.
    Cell Death Discov. (2018) 5:3. doi: 10.1038/s41420-018-0068-z.
  • 123) Ogawa M, Matsuda R, Takada N, Tomokiyo M, Yamamoto S, Shizukusihi S, Yamaji T, Yoshikawa Y, Yoshida M, Tanida I, Koike M, Murai M, Morita H, Takeyama H, Ryo A, Guan JL, Yamamoto M, Inoue JI, Yanagawa T, Fukuda M, Kawabe H, Ohnishi M.
    Molecular mechanisms of Streptococcus pneumoniae-targeted autophagy via pneumolysin, Golgi-resident Rab41, and Nedd4-1-mediated K63-linked ubiquitination.
    Cell Microbiol. (2018) 20:e12846. doi: 10.1111/cmi.12846.
  • 122) Sasai M, Pradipta A, Yamamoto M (Corresponding author).
    Host immune responses to Toxoplasma gondii.
    Int Immunol. (2018) 30:113-119. doi: 10.1093/intimm/dxy004.
  • 121) Santos JC, Dick MS, Lagrange B, Degrandi D, Pfeffer K, Yamamoto M, Meunier E, Pelczar P, Henry T, Broz P.
    LPS targets host guanylate-binding proteins to the bacterial outer membrane for non-canonical inflammasome activation.
    MBO J. (2018) Mar 15;37(6). pii: e98089.
  • 120) Finethy R, Luoma S, Orench-Rivera N, Feeley EM, Haldar AK, Yamamoto M, Kanneganti TD, Kuehn MJ, Coers J.
    Inflammasome Activation by Bacterial Outer Membrane Vesicles Requires Guanylate Binding Proteins.
    MBio. 2017 Oct 3;8(5). pii: e01188-17.
  • 119) Wallet P, Benaoudia S, Mosnier A, Lagrange B, Martin A, Lindgren H, Golovliov I, Michal F, Basso P, Djebali S, Provost A, Allatif O, Meunier E, Broz P, Yamamoto M, Py BF, Faudry E, Sjöstedt A, Henry T.
    IFN-γ extends the immune functions of Guanylate Binding Proteins to inflammasome-independent antibacterial activities during Francisella novicida infection.
    PLoS Pathog. (2017) Oct 2;13(10):e1006630.
  • 118) Chida T, Ito M, Nakashima K, Kanegae Y, Aoshima T, Takabayashi S, Kawata K, Nakagawa Y, Yamamoto M, Shimano H, Matsuura T, Kobayashi Y, Suda T, Suzuki T.
    Critical role of CREBH-mediated induction of TGF-β2 by HCV infection in fibrogenic responses in hepatic stellate cells.
    Hepatology. (2017) Nov;66(5):1430-1443.
  • 117) Zwack EE, Feeley E, Burton AR, Hu B, Yamamoto M, Kanneganti TD, Bliska JB, Coers J, Brodsky IE.
    Guanylate Binding Proteins regulate inflammasome activation in response to hyper-injected Yersinia translocon components.
    Infect Immun. (2017) 85(10). pii: e00778-16.
  • 116) Biering SB, Choi J, Halstrom RA, Brown HM, Beatty WL, Lee S, McCune BT, Dominici E, Williams LE, Orchard RC, Wilen CB, Yamamoto M, Coers J, Taylor GA, Hwang S.
    Viral Replication Complexes Are Targeted by LC3-Guided Interferon-Inducible GTPases.
    Cell Host Microbe. (2017) 22:74-85.e7.
  • 115) Sasai M, Sakaguchi N, Ma JS, Nakamura S, Kawabata T, Bando H, Lee Y, Saitoh T, Akira S, Iwasaki A, Standley DM, Yoshimori T, Yamamoto M (Corresponding author).
    Essential role for GABARAP autophagy proteins in interferon-inducible GTPase-mediated host defense.
    Nat Immunol. (2017) 18:899-910.
  • 114) Man SM, Karki R, Sasai M, Place DE, Kesavardhana S, Temirov J, Frase S, Zhu Q, Malireddi RK, Kuriakose T, Peters JL, Neale G, Brown SA, Yamamoto M, Kanneganti TD.
    IRGB10 Liberates Bacterial Ligands for Sensing by the AIM2 and Caspase-11-NLRP3 Inflammasomes.
    Cell. (2016) 167:382-396.
  • 113) Ozaki T, Muramatsu R, Sasai M, Yamamoto M, Kubota Y, Fujinaka T, Yoshimine T, Yamashita T.
    The P2X4 receptor is required for neuroprotection via ischemic preconditioning.
    Sci Rep. (2016) 6:25893.
  • 112) Aizawa S, Okamoto T, Sugiyama Y, Kouwaki T, Ito A, Suzuki T, Ono C, Fukuhara T, Yamamoto M, Okochi M, Hiraga N, Imamura M, Chayama K, Suzuki R, Shoji I, Moriishi K, Moriya K, Koike K, Matsuura Y.
    TRC8-dependent degradation of hepatitis C virus immature core protein regulates viral propagation and pathogenesis.
    Nat Commun. (2016) 7:11379.
  • 111) Okumura R, Kurakawa T, Nakano T, Kayama H, Kinoshita M, Motooka D, Gotoh K, Kimura T, Kamiyama N, Kusu T, Ueda Y, Wu H, Iijima H, Barman S, Osawa H, Matsuno H, Nishimura J, Ohba Y, Nakamura S, Iida T, Yamamoto M, Umemoto E, Sano K, Takeda K.
    Lypd8 promotes the segregation of flagellated microbiota and colonic epithelia.
    Nature. (2016) 532:117-21.
  • 110) Finethy R, Jorgensen I, Haldar AK, de Zoete MR, Strowig T, Flavell RA, Yamamoto M, Nagarajan UM, Miao EA, Coers J.
    Guanylate binding proteins enable rapid activation of canonical and noncanonical inflammasomes in Chlamydia-infected macrophages.
    Infect Immun. (2015) 83:4740-9.
  • 109) Hammoudi PM, Jacot D, Mueller C, Di Cristina M, Dogga SK, Marq JB, Romano J, Tosetti N, Dubrot J, Emre Y, Lunghi M, Coppens I, Yamamoto M, Sojka D, Pino P, Soldati-Favre D.
    Fundamental Roles of the Golgi-Associated Toxoplasma Aspartyl Protease, ASP5, at the Host-Parasite Interface.
    PLoS Pathog. (2015) 11:e1005211.
  • 108) Lee Y, Sasai M, Ma J, Sakaguchi N, Ohshima J, Bando H, Saitoh T, Akira S, Yamamoto M (Corresponding author).
    p62 plays a specific role in interferon-γ-induced presentation of a Toxoplasma vacuolar antigen.
    Cell Rep. (2015) 13:223-233.
  • 107) Ohshima J, Sasai M, Liu J, Yamashita K, Ma JS, Lee Y, Bando H, Howard JC, Ebisu S, Hayashi M, Takeda K, Standley DM, Frickel EM, Yamamoto M (Corresponding author).
    RabGDIα is a negative regulator of interferon-γ-inducible GTPase-dependent cell-autonomous immunity to Toxoplasma gondii.
    Proc Natl Acad Sci U S A. (2015) 112:E4581-4590.
  • 106) Ito D, Nojima S, Nishide M, Okuno T, Takamatsu H, Kang S, Kimura T, Yoshida Y, Morimoto K, Maeda Y, Hosokawa T, Toyofuku T, Ohshima J, Kamimura D, Yamamoto M, Murakami M, Morii E, Rakugi H, Isaka Y, Kumanogoh A.
    mTOR Complex Signaling through the SEMA4A-Plexin B2 Axis Is Required for Optimal Activation and Differentiation of CD8+ T Cells.
    J Immunol. (2015) 195:934-43. doi:10.4049/jimmunol.1403038.
  • 105) Meunier E, Wallet P, Dreier RF, Costanzo S, Anton L, Rühl S, Dussurgey S, Dick MS, Kistner A, Rigard M, Degrandi D, Pfeffer K, Yamamoto M, Henry T, Broz P.
    Guanylate-binding proteins promote activation of the AIM2 inflammasome during infection with Francisella novicida.
    Nat Immunol. (2015) 16:476-484.
  • 104) Man SM, Karki R, Malireddi RK, Neale G, Vogel P, Yamamoto M, Lamkanfi M, Kanneganti TD.
    The transcription factor IRF1 and guanylate-binding proteins target activation of the AIM2 inflammasome by Francisella infection.
    Nat Immunol. (2015) 16:467-475.
  • 103) Fukuhara T, Wada M, Nakamura S, Ono C, Shiokawa M, Yamamoto S, Motomura T, Okamoto T, Okuzaki D, Yamamoto M, Saito I, Wakita T, Koike K, Matsuura Y.
    Amphipathic α-helices in apolipoproteins are crucial to the formation of infectious hepatitis C virus particles.
    PLoS Pathog. (2014) 10:e1004534. doi: 10.1371/journal.ppat.1004534.
  • 102) Ma JS, Sasai M, Ohshima J, Lee Y, Bando H, Takeda K, Yamamoto M (Corresponding author).
    Selective and strain-specific NFAT4 activation by the Toxoplasma gondii polymorphic dense granule protein GRA6.
    J Exp Med. (2014) 211:2013-32.
  • 101) Pilla DM, Hagar JA, Haldar AK, Mason AK, Degrandi D, Pfeffer K, Ernst RK, Yamamoto M, Miao EA, Coers J.
    Guanylate binding proteins promote caspase-11-dependent pyroptosis in response to cytoplasmic LPS.
    Proc Natl Acad Sci U S A. (2014) 111:6046-51.
  • 100) Meunier E, Dick MS, Dreier RF, Schürmann N, Kenzelmann Broz D, Warming S, Roose-Girma M, Bumann D, Kayagaki N, Takeda K, Yamamoto M, Broz P.
    Caspase-11 activation requires lysis of pathogen-containing vacuoles by IFN-induced GTPases.
    Nature. (2014) 509:366-70.
  • 99) Ohshima J, Lee Y, Sasai M, Saitoh T, Ma JS, Kamiyama N, Matsuura Y, Pann-Ghill S, Hayashi M, Ebisu S, Takeda K, Akira S, Yamamoto M (Corresponding author).
    Role of the mouse and human autophagy proteins in IFN-γ-induced cell-autonomous responses against Toxoplasma gondii.
    J Immunol. (2014) 192: 3328-3335.
  • 98) Haldar AK, Piro AS, Pilla DM, Yamamoto M, Coers J.
    The E2-Like Conjugation Enzyme Atg3 Promotes Binding of IRG and Gbp Proteins to Chlamydia- and Toxoplasma-Containing Vacuoles and Host Resistance.
    PLoS One. (2014) 9:e86684.
  • 97) Ono C, Ninomiya A, Yamamoto S, Abe T, Wen X, Fukuhara T, Sasai M, Yamamoto M, Saitoh T, Satoh T, Kawai T, Ishii KJ, Akira S, Okamoto T, Matsuura Y.
    Innate immune response induced by baculovirus attenuates transgene expression in mammalian cells.
    J Virol. (2014) 88:2157-2167.
  • 96) Kimura T, Katoh H, Kayama H, Saiga H, Okuyama M, Okamoto T, Umemoto E, Matsuura Y, Yamamoto M, Takeda K.
    Ifit1 inhibits Japanese encephalitis virus replication through binding to 5' capped 2'-O unmethylated RNA.
    J Virol. (2013) 87:9997-10003.
  • 95) Sasai M, Yamamoto M (Corresponding author).
    Pathogen Recognition Receptors: Ligands and Signaling Pathways by Toll-like Receptors.
    Int Rev Immunol. (2013) 32:116-33.
  • 94) Kemp LE, Yamamoto M, Soldati-Favre D.
    Subversion of host cellular functions by the apicomplexan parasites.
    FEMS Microbiol Rev. (2013) 37:607-31.
  • 93) Satoh T, Kidoya H, Naito H, Yamamoto M, Takemura N, Nakagawa K, Yoshioka Y, Morii E, Takakura N, Takeuchi O, Akira S.
    Critical role of Trib1 for the differentiation of adipose tissue-resident macrophages maintaining metabolic homeostasis.
    Nature. (2013) 495:524-8.
  • 92) Lundberg AM, Ketelhuth DF, Johansson ME, Gerdes N, Liu S, Yamamoto M, Akira S, Hansson GK.
    Toll-like receptor 3 and 4 signalling through the TRIF and TRAM adaptors in hematopoietic cells promotes atherosclerosis.
    Cardiovasc Res. (2013) 99:364-73.
  • 91) Kamiyama N, Yamamoto M (Equal contribution, Co-corresponding author), Saiga H, Ma JS, Ohshima J, Machimura S, Sasai M, Kimura T, Ueda Y, Kayama H, Takeda K.
    CREBH Determines the Severity of Sulpyrine-Induced Fatal Shock.
    PLoS One. (2013) 8:e55800.
  • 90) Kusu T, Kayama H, Kinoshita M, Jeon SG, Ueda Y, Goto Y, Okumura R, Saiga H, Kurakawa T, Ikeda K, Maeda Y, Nishimura J, Arima Y, Atarashi K, Honda K, Murakami M, Kunisawa J, Kiyono H, Okumura M, Yamamoto M, Takeda K.
    Ecto-Nucleoside Triphosphate Diphosphohydrolase 7 Controls Th17 Cell Responses through Regulation of Luminal ATP in the Small Intestine.
    J Immunol. (2013) 190:774-783.
  • 89) Yamamoto M, Okuyama M, Ma JS, Kimura T, Kamiyama N, Saiga H, Ohshima J, Sasai M, Kayama H, Okamoto T, Huang DS, Soldati-Favre D, Horie K, Takeda J, Takeda K.
    A cluster of interferon-γ-inducible p65 GTPases plays a critical role in host defense against Toxoplasma gondii.
    Immunity. (2012) 37:302-313.
  • 88) Saiga H, Kitada S, Shimada Y, Kamiyama N, Okuyama M, Makino M, Yamamoto M, Takeda K.
    Critical role of AIM2 in Mycobacterium tuberculosis infection.
    Int Immunol. (2012) 24:637-44.
  • 87) Jeon SG, Kayama H, Ueda Y, Takahashi T, Asahara T, Tsuji H, Tsuji NM, Kiyono H, Ma JS, Kusu T, Okumura R, Hara H, Yoshida H, Yamamoto M, Nomoto K, Takeda K.
    Probiotic Bifidobacterium breve Induces IL-10-Producing Tr1 Cells in the Colon.
    PLoS Pathog. (2012) 8:e1002714.
  • 86) Kayama H, Ueda Y, Sawa Y, Jeon SG, Ma JS, Okumura R, Kubo A, Ishii M, Okazaki T, Murakami M, Yamamoto M, Yagita H, Takeda K.
    Intestinal CX3C chemokine receptor 1(high) (CX3CR1(high)) myeloid cells prevent T-cell-dependent colitis.
    Proc Natl Acad Sci U S A. (2012) 109:5010-5.
  • 85) Yamamoto M, Takeda K.
    Inhibition of ATF6β-dependent host adaptive immune response by a Toxoplasma virulence factor ROP18.
    Virulence. (2012) 3:77-80.
  • 84) Yamamoto M, Takeda K.
    A method for the generation of conditional gene-targeted mice.
    Methods Mol Biol. (2012) 757:399-410.
  • 83) Yamamoto M, Ma JS, Mueller C, Kamiyama N, Saiga H, Kubo E, Kimura T, Okamoto T, Okuyama M, Kayama H, Nagamune K, Takashima S, Matsuura Y, Soldati-Favre D, Takeda K.
    ATF6b is a host cellular target of the Toxoplasma gondii virulence factor ROP18.
    J Exp Med. (2011) 208:1533-1546.
  • 82) Yamamoto M, Takeda K.
    Current views of toll-like receptor signaling pathways.
    Gastroenterol Res Pract. (2010):240365.
  • 81) Ueda Y, Kayama H, Jeon SG, Kusu T, Isaka Y, Rakugi H, Yamamoto M, Takeda K.
    Commensal microbiota induce LPS hyporesponsiveness in colonic macrophages via the production of IL-10.
    Int Immunol. (2010) 22:953-62.
  • 80) Burkhardt R, Toh SA, Lagor WR, Birkeland A, Levin M, Li X, Robblee M, Fedorov VD, Yamamoto M, Satoh T, Akira S, Kathiresan S, Breslow JL, Rader DJ.
    Trib1 is a lipid- and myocardial infarction-associated gene that regulates hepatic lipogenesis and VLDL production in mice.
    J Clin Invest. (2010) 120:4410-4.
  • 79) Yamamoto M, Akira S.
    Lipid A Receptor TLR4-Mediated Signaling Pathways.
    Adv Exp Med Biol. (2010) 667:59-68.
  • 78) Sayama K*, Yamamoto M* (* Equal contribution), Shirakata Y, Hanakawa Y, Hirakawa S, Dai X, Tohyama M, Tokumaru S, Shin MS, Sakurai H, Akira S, Hashimoto K.
    E2 polyubiquitin-conjugating enzyme Ubc13 in keratinocytes is essential for epidermal integrity.
    J Biol Chem. (2010) 285:30042-9.
  • 77) Okuyama M, Kayama H, Atarashi K, Saiga H, Kimura T, Waisman A, Yamamoto M, Takeda K.
    A novel in vivo inducible dendritic cell ablation model in mice.
    Biochem Biophys Res Commun. (2010) 397:559-63.
  • 76) Ostertag A, Jones A, Rose AJ, Liebert M, Kleinsorg S, Reimann A, Vegiopoulos A, Berriel Diaz M, Strzoda D, Yamamoto M, Satoh T, Akira S, Herzig S.
    Control of adipose tissue inflammation through TRB1.
    Diabetes. (2010) 59:1991-2000.
  • 75) Okamoto K, Iwai Y, Oh-hora M, Yamamoto M, Morio T, Aoki K, Ohya K, Jetten AM, Akira S, Takayanagi H.
    IκBζ regulates TH17 development by cooperating with ROR nuclear receptors.
    Nature. (2010) 464:1381-1385.
  • 74) Ogawa M, Yamamoto M, Takeda K.
    Role of Toxoplasma gondii rhoptry kinase ROP16 in Stat6 activation.
    Medical Journal Osaka University. (2010) 53: 1-4.
  • 73) Talbot S, Tötemeyer S, Yamamoto M, Akira S, Hughes K, Gray D, Barr T, Mastroeni P, Maskell DJ, Bryant CE.
    Toll-like receptor 4 signalling through MyD88 is essential to control Salmonella enterica serovar Typhimurium infection, but not for the initiation of bacterial clearance.
    Immunology. (2009) 128:472-83.
  • 72) Wu X, Yamamoto M, Akira S, Sun SC.
    Regulation of hematopoiesis by the K63-specific ubiquitin-conjugating enzyme Ubc13.
    Proc Natl Acad Sci U S A. (2009) 106:20836-41.
  • 71) Yamamoto M, Standley DM, Takashima S, Saiga H, Okuyama M, Kayama H, Kubo E, Ito H, Takaura M, Matsuda T, Soldati-Favre D, Takeda K.
    A single polymorphic amino acid on Toxoplasma gondii kinase ROP16 determines the direct and strain-specific activation of Stat3.
    J Exp Med. (2009) 206: 2747-2760.
  • 70) Yamazaki K, Gohda J, Kanayama A, Miyamoto Y, Sakurai H, Yamamoto M, Akira S, Hayashi H, Su B, Inoue J.
    Two Mechanistically and Temporally Distinct NF-κB Activation Pathways in IL-1 Signaling.
    Sci Signal. (2009) 2:ra66.
  • 69) Kayama H, Koga R, Atarashi K, Okuyama M, Kimura T, Mak TW, Uematsu S, Akira S, Takayanagi H, Honda K, Yamamoto M, Takeda K.
    NFATc1 mediates Toll-like receptor-independent innate immune responses during Trypanosoma cruzi infection. PLoS Pathog. (2009) 5:e1000514.
  • 68) Kobayashi T, Kim TS, Jacob A, Walsh MC, Kadono Y, Fuentes-Pananá E, Yoshioka T, Yoshimura A, Yamamoto M, Kaisho T, Akira S, Monroe JG, Choi Y.
    TRAF6 is required for generation of the B-1a B cell compartment as well as T cell-dependent and -independent humoral immune responses.
    PLoS One. (2009) 4:e4736.
  • 67) Tokunaga F, Sakata S, Saeki Y, Satomi Y, Kirisako T, Kamei K, Nakagawa T, Kato M, Murata S, Yamaoka S, Yamamoto M, Akira S, Takao T, Tanaka K, Iwai K.
    Involvement of linear polyubiquitylation of NEMO in NF-κB activation.
    Nat Cell Biol. (2009) 11:123-32.
  • 66) Saiga H, Nishimura J, Kuwata H, Okuyama M, Matsumoto S, Sato S, Matsumoto M, Akira S, Yoshikai Y, Honda K, Yamamoto M, Takeda K.
    Lipocalin 2-dependent inhibition of mycobacterial growth in alveolar epithelium.
    J Immunol. (2008) 181:8521-7.
  • 65) Yamazaki S, Matsuo S, Muta T, Yamamoto M, Akira S, Takeshige K.
    Gene-specific requirement of a nuclear protein, IκB-z, for promoter association of inflammatory transcription regulators.
    J Biol Chem. (2008) 283:32404-11.
  • 64) Huen MS, Huang J, Yuan J, Yamamoto M, Akira S, Ashley C, Xiao W, Chen J.
    Noncanonical E2 variant-independent function of UBC13 in promoting checkpoint protein assembly.
    Mol Cell Biol. (2008) 28:6104-12.
  • 63) Atarashi K, Nishimura J, Shima T, Umesaki Y, Yamamoto M, Onoue M, Yagita H, Ishii N, Evans R, Honda K, Takeda K.
    ATP drives lamina propria Th17 cell differentiation.
    Nature. (2008) 455:808-12.
  • 62) Yamamoto M, Takeda K.
    Role of nuclear IκB proteins in the regulation of host immune responses.
    J Infect Chemother. (2008) 14:265-9.
  • 61）Ueta M, Hamuro J, Ueda E, Katoh N, Yamamoto M, Takeda K, Akira S, Kinoshita S.
    Stat6-independent tissue inflammation occurs selectively on the ocular surface and perioral skin of IκBζ-/- mice.
    Invest Ophthalmol Vis Sci. (2008) 49:3387-94.
  • 60) Nishimura J, Saiga H, Sato S, Okuyama M, Kayama H, Kuwata H, Matsumoto S, Nishida T, Sawa Y, Akira S, Yoshikai Y, Yamamoto M, Takeda K.
    Potent antimycobacterial activity of mouse secretory leukocyte protease inhibitor.
    J Immunol. (2008) 180:4032-9.
  • 59) Kayama H, Ramirez-Carrozzi VR, Yamamoto M, Mizutani T, Kuwata H, Iba H, Matsumoto M, Honda K, Smale ST, Takeda K.
    Class-specific Regulation of Pro-inflammatory Genes by MyD88 Pathways and IκBζ.
    J Biol Chem. (2008) 283:12468-77.
  • 58) Foster GL, Barr TA, Grant AJ, McKinley TJ, Bryant CE, Macdonald A, Gray D, Yamamoto M, Akira S, Maskell DJ, Mastroeni P.
    Virulent Salmonella enterica infections can be exacerbated by concomitant infection of the host with a live attenuated S. enterica vaccine via Toll-like receptor 4-dependent interleukin-10 production with the involvement of both TRIF and MyD88.
    Immunology. (2008) 124:469-79.
  • 57) Shembade N, Harhaj NS, Yamamoto M, Akira S, Harhaj EW.
    The HTLV-I Tax oncoprotein requires the ubiquitin conjugating enzyme Ubc13 for NF-κB activation.
    J Virol. (2007) 81:13735-42.
  • 56) Uematsu S, Kaisho T, Tanaka T, Matsumoto M, Yamakami M, Omori H, Yamamoto M, Yoshimori T, Akira S.
    The C/EBP Isoform 34-kDa LAP Is Responsible for NF-IL-6-Mediated GeneInduction in Activated Macrophages, but Is Not Essential for Intracellular Bacteria Killing.
    J Immunol. (2007) 179:5378-86.
  • 55) Biswas SK, Bist P, Dhillon MK, Kajiji T, Del Fresno C, Yamamoto M, Lopez-Collazo E, Akira S, Tergaonkar V.
    Role for MyD88-independent, TRIF pathway in lipid A/TLR4-induced endotoxintolerance.
    J Immunol. (2007) 179:4083-92.
  • 54) Zhande R, Dauphinee SM, Thomas JA, Yamamoto M, Akira S, Karsan A.
    FADD Negatively Regulates Lipopolysaccharide Signaling by Impairing Interleukin-1 Receptor-Associated Kinase 1-MyD88 Interaction.
    Mol Cell Biol. (2007) 27:7394-404.
  • 53) Yamamoto M, Uematsu S, Okamoto T, Matsuura Y, Sato S, Kumar H, Satoh T, Saitoh T, Takeda K, Ishii KJ, Takeuchi O, Kawai T, Akira S.
    Enhanced TLR-mediated NF-IL6 dependent gene expression by Trib1 deficiency.
    J Exp Med. (2007) 204:2233-9.
  • 52) Cook P, Totemeyer S, Stevenson C, Fitzgerald KA, Yamamoto M, Akira S, Maskell DJ, Bryant CE.
    Salmonella-induced SipB-independent cell death requires Toll-like receptor-4 signalling via the adapter proteins Tram and Trif.
    Immunology. (2007) 122:222-9.
  • 51) Kawagoe T, Sato S, Jung A, Yamamoto M, Matsui K, Kato H, Uematsu S, Takeuchi O, Akira S.
    Essential role of IRAK-4 protein and its kinase activity in Toll-likereceptor-mediated immune responses but not in TCR signaling.
    J Exp Med. (2007) 204:1013-24.
  • 50) Miggin SM, Palsson-McDermott E, Dunne A, Jefferies C, Pinteaux E, Banahan K, Murphy C, Moynagh P, Yamamoto M, Akira S, Rothwell N, Golenbock D, Fitzgerald KA, O'Neill LA.
    NF-κB activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1.
    Proc Natl Acad Sci U S A. (2007) 104:3372-7.
  • 49) Power MR, Li B, Yamamoto M, Akira S, Lin TJ.
    A role of Toll-IL-1 receptor domain-containing adaptor-inducing IFN-β in the host response to Pseudomonas aeruginosa lung infection in mice.
    J Immunol. (2007) 178:3170-6.
  • 48) Jeyaseelan S, Young SK, Fessler MB, Liu Y, Malcolm KC, Yamamoto M, Akira S, Worthen GS.
    Toll/IL-1 receptor domain-containing adaptor inducing IFN-β (TRIF)-mediated signaling contributes to innate immune responses in the lung during Escherichia coli pneumonia.
    J Immunol. (2007) 178:3153-60.
  • 47) Coban C, Ishii KJ, Uematsu S, Arisue N, Sato S, Yamamoto M, Kawai T, Takeuchi O, Hisaeda H, Horii T, Akira S.
    Pathological role of Toll-like receptor signaling in cerebral malaria.
    Int Immunol. (2007) 19:67-79.
  • 46) Yamamoto M, Sato S, Saitoh T, Sakurai H, Uematsu S, Kawai T, Ishii KJ, Takeuchi O, Akira S.
    Cutting Edge: Pivotal Function of Ubc13 in Thymocyte TCR Signaling.
    J Immunol. 2006 177:7520-4.
  • 45) Koga R, Hamano S, Kuwata H, Atarashi K, Ogawa M, Hisaeda H, Yamamoto M, Akira S, Himeno K, Matsumoto M, Takeda K.
    TLR-Dependent Induction of IFN-b Mediates Host Defense against Trypanosoma cruzi.
    J Immunol. (2006) 177:7059-66.
  • 44) Power MR, Marshall JS, Yamamoto M, Akira S, Lin TJ.
    The myeloid differentiation factor 88 is dispensable for the development of a delayed host response to Pseudomonas aeruginosa lung infection in mice.
    Clin Exp Immunol. (2006) 146:323-9.
  • 43) Bhattacharjee RN, Park KS, Kumagai Y, Okada K, Yamamoto M, Uematsu S, Matsui K, Kumar H, Kawai T, Iida T, Honda T, Takeuchi O, Akira S.
    VP1686, a Vibrio type III secretion protein, induces toll-like receptor independent apoptosis in macrophage through NF-κB inhibition.
    J Biol Chem. (2006) 281:36897-904.
  • 42) Sato S, Sanjo H, Tsujimura T, Ninomiya-Tsuji J, Yamamoto M, Kawai T, Takeuchi O, Akira S.
    TAK1 is indispensable for development of T cells and prevention of colitis by the generation of regulatory T cells.
    Int Immunol. (2006) 18:1405-11.
  • 41) Yamamoto M, Okamoto T, Takeda K, Sato S, Sanjo H, Uematsu S, Saitoh T, Yamamoto N, Sakurai H, Ishii KJ, Yamaoka S, Kawai T, Matsuura Y, Takeuchi O, Akira S.
    Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling.
    Nat Immunol. (2006) 7:962-70.
  • 40) Uematsu S, Jang MH, Chevrier N, Guo Z, Kumagai Y, Yamamoto M, Kato H, Sougawa N, Matsui H, Kuwata H, Hemmi H, Coban C, Kawai T, Ishii KJ, Takeuchi O, Miyasaka M, Takeda K, Akira S.
    Detection of pathogenic intestinal bacteria by Toll-like receptor 5 on intestinal CD11c+ lamina propria cells.
    Nat Immunol. (2006) 7:868-74.
  • 39) Jeyaseelan S, Young SK, Yamamoto M, Arndt PG, Akira S, Kolls JK, Worthen GS.
    Toll/IL-1R Domain-Containing Adaptor Protein (TIRAP) Is a Critical Mediator of Antibacterial Defense in the Lung against Klebsiella pneumoniae but Not Pseudomonas aeruginosa.
    J Immunol. (2006) 177:538-47.
  • 38) Kumar H, Kawai T, Kato H, Sato S, Takahashi K, Coban C, Yamamoto M, Uematsu S, Ishii KJ, Takeuchi O, Akira S.
    Essential role of IPS-1 in innate immune responses against RNA viruses.
    J Exp Med. (2006) 203:1795-803.
  • 37) Saitoh T, Tun-Kyi A, Ryo A, Yamamoto M, Finn G, Fujita T, Akira S, Yamamoto N, Lu KP, Yamaoka S.
    Negative regulation of interferon-regulatory factor 3-dependent innate antiviral response by the prolyl isomerase Pin1.
    Nat Immunol. (2006) 7:598-605.
  • 36) Kelly KM, Zhuang H, Nacionales DC, Scumpia PO, Lyons R, Akaogi J, Lee P, Williams B, Yamamoto M, Akira S, Satoh M, Reeves WH.
    "Endogenous adjuvant" activity of the RNA components of lupus autoantigens Sm/RNP and Ro 60.
    Arthritis Rheum. (2006) 54:1557-67.
  • 35) Kato H, Takeuchi O, Sato S, Yoneyama M, Yamamoto M, Matsui K, Uematsu S, Jung A, Kawai T, Ishii KJ, Yamaguchi O, Otsu K, Tsujimura T, Koh CS, Reis E Sousa C, Matsuura Y, Fujita T, Akira S.
    Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses.
    Nature. (2006) 441:101-5.
  • 34) Rowe DC, McGettrick AF, Latz E, Monks BG, Gay NJ, Yamamoto M, Akira S, O'neill LA, Fitzgerald KA, Golenbock DT.
    The myristoylation of TRIF-related adaptor molecule is essential for Toll-like receptor 4 signal transduction.
    Proc Natl Acad Sci U S A. (2006) 103:6299-304.
  • 33) Fischer H, Yamamoto M, Akira S, Beutler B, Svanborg C.
    Mechanism of pathogen-specific TLR4 activation in the mucosa: Fimbriae, recognition receptors and adaptor protein selection.
    Eur J Immunol. (2006) 36:267-77.
  • 32) Wan J, Zhang W, Wu L, Bai T, Zhang M, Lo KW, Chui YL, Cui Y, Tao Q, Yamamoto M, Akira S, Wu Z.
    BS69, a Specific Adaptor in the Latent Membrane Protein 1-Mediated c-Jun N-Terminal Kinase Pathway.
    Mol Cell Biol. (2006) 26:448-56.
  • 31) Jeyaseelan S, Manzer R, Young SK, Yamamoto M, Akira S, Mason RJ, Worthen GS.
    Toll-IL-1 Receptor Domain-Containing Adaptor Protein Is Critical for Early Lung Immune Responses against Escherichia coli Lipopolysaccharide and Viable Escherichia coli.
    J Immunol. (2005) 175:7484-95.
  • 30) Ishii KJ, Coban C, Kato H, Takahashi K, Torii Y, Takeshita F, Ludwig H, Sutter G, Suzuki K, Hemmi H, Sato S, Yamamoto M, Uematsu S, Kawai T, Takeuchi O, Akira S.
    A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA.
    Nat Immunol. (2006) 7:40-8.
  • 29) Yamamoto M, Akira S.
    Mechanisms of innate immune responses mediated by Toll-like receptors.
    Clinical and Applied Immunology Reviews. (2005) 5: 167-83.
  • 28) Yamamoto M, Akira S.
    Tir domain-containing adaptors regulate TLR signaling pathways.
    Advances in Experimental Medicine and Biology. (2005) 560: 1-9.
  • 27) Rothenfusser S, Goutagny N, Diperna G, Gong M, Monks BG, Schoenemeyer A, Yamamoto M, Akira S, Fitzgerald KA.
    The RNA Helicase Lgp2 Inhibits TLR-Independent Sensing of Viral Replication by Retinoic Acid-Inducible Gene-I.
    J Immunol. (2005) 175:5260-8
  • 26) Sato S, Sanjo H, Takeda K, Ninomiya-Tsuji J, Yamamoto M, Kawai T, Matsumoto K, Takeuchi O, Akira S.
    Essential function for the kinase TAK1 in innate and adaptive immune responses.
    Nat Immunol. (2005) 6:1087-95.
  • 25) Kato H, Sato S, Yoneyama M, Yamamoto M, Uematsu S, Matsui K, Tsujimura T, Takeda K, Fujita T, Takeuchi O, Akira S.
    Cell Type-Specific Involvement of RIG-I in Antiviral Response.
    Immunity. (2005) 23:19-28.
  • 24) Shindou H, Ishii S, Yamamoto M, Takeda K, Akira S, Shimizu T.
    Priming Effect of Lipopolysaccharide on Acetyl-Coenzyme A:Lyso-Platelet-Activating Factor Acetyltransferase Is MyD88 and TRIF Independent.
    J Immunol. (2005) 175:1177-83
  • 23) Jeyaseelan S, Manzer R, Young SK, Yamamoto M, Akira S, Mason RJ, Worthen GS.
    Induction of CXCL5 During Inflammation in the Rodent Lung Involves Activation of Alveolar Epithelium.
    Am J Respir Cell Mol Biol. (2005) 32:531-9.
  • 22) Uematsu S, Sato S, Yamamoto M, Hirotani T, Kato H, Takeshita F, Matsuda M, Coban C, Ishii KJ, Kawai T, Takeuchi O, Akira S.
    Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-α induction.
    J Exp Med. 2005 201:915-23.
  • 21) Hirotani T, Lee PY, Kuwata H, Yamamoto M, Matsumoto M, Kawase I, Akira S, Takeda K.
    The Nuclear IκB Protein IκBNS Selectively Inhibits Lipopolysaccharide-Induced IL-6 Production in Macrophages of the Colonic Lamina Propria.
    J Immunol. (2005) 174:3650-7.
  • 20) Hirotani T, Yamamoto M, Kumagai Y, Uematsu S, Kawase I, Takeuchi O, Akira S.
    Regulation of lipopolysaccharide-inducible genes by MyD88 and Toll/IL-1 domain containing adaptor inducing IFN-β.
    Biochem Biophys Res Commun. (2005) 328:383-92.
  • 19) Ueta M, Hamuro J, Yamamoto M, Kaseda K, Akira S, Kinoshita S.
    Spontaneous Ocular Surface Inflammation and Goblet Cell Disappearancein IκBζ Gene-Disrupted Mice.
    Invest Ophthalmol Vis Sci. (2005) 46:579-88.
  • 18) Saitoh T, Yamamoto M, Miyagishi M, Taira K, Nakanishi M, Fujita T, Akira S, Yamamoto N, Yamaoka S.
    A20 Is a Negative Regulator of IFN Regulatory Factor 3 Signaling.
    J Immunol. (2005) 174:1507-1512
  • 17) Coban C, Ishii KJ, Kawai T, Hemmi H, Sato S, Uematsu S, Yamamoto M, Takeuchi O, Itagaki S, Kumar N, Horii T, Akira S.
    Toll-like receptor 9 mediates innate immune activation by the malaria pigment hemozoin.
    J Exp Med. (2005) 201:19-25.
  • 16) Stockinger S, Reutterer B, Schaljo B, Schellack C, Brunner S, Materna T, Yamamoto M, Akira S, Taniguchi T, Murray PJ, Muller M, Decker T.
    IFN regulatory factor 3-dependent induction of type I IFNs by intracellular bacteria is mediated by a TLR- and Nod2-independent mechanism.
    J Immunol. (2004) 173:7416-25.
  • 15) Yamamoto M, Yaginuma K, Tsutsui H, Sagara J, Guan X, Seki E, Yasuda K, Yamamoto M, Akira S, Nakanishi K, Noda T, Taniguchi S.
    ASC is essential for LPS-induced activation of procaspase-1 independently of TLR-associated signal adaptor molecules.
    Genes Cells. (2004) 9:1055-67.
  • 14) TenOever BR, Sharma S, Zou W, Sun Q, Grandvaux N, Julkunen I, Hemmi H, Yamamoto M, Akira S, Yeh WC, Lin R, Hiscott J.
    Activation of TBK1 and IKK-e Kinases by Vesicular Stomatitis Virus Infection and the Role of Viral Ribonucleoprotein in the Development of Interferon Antiviral Immunity.
    J Virol. (2004) 78:10636-10649.
  • 13) Kawai T, Sato S, Ishii KJ, Coban C, Hemmi H, Yamamoto M, Terai K, Matsuda M, Inoue JI, Uematsu S, Takeuchi O, Akira S.
    Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6.
    Nat Immunol. (2004) 5:1061-8.
  • 12) Fujimori J, Nakashima I, Fujihara K, Feng J, Yamamoto M, Yamamoto N, Begum N, Sagara Y, Shiraki H, Shiga Y, Onodera J, Sato S, Takase S, Asano M, Endo M, Itoyama Y.
    Epitope analysis of the cerebrospinal fluid IgG in HTLV-I associated myelopathy patients using phage display method.
    J Neuroimmunol. (2004) 152:140-6.
  • 11) Sato N, Takahashi N, Suda K, Nakamura M, Yamaki M, Ninomiya T, Kobayashi Y, Takada H, Shibata K, Yamamoto M, Takeda K, Akira S, Noguchi T, Udagawa N.
    MyD88 But Not TRIF Is Essential for Osteoclastogenesis Induced by Lipopolysaccharide, DiacylLipopeptide, and IL-1β.
    J Exp Med. (2004) 200:601-611.
  • 10) Yamamoto M, Yamazaki S, Uematsu S, Sato S, Hemmi H, Hoshino K, Kaisho T, Kuwata H, Takeuchi O, Takeshige K, Saitoh T, Yamaoka S, Yamamoto N, Yamamoto S, Muta T, Takeda K, Akira S.
    Regulation of Toll/IL-1-receptor-mediated gene expression by the inducible nuclear protein IκBζ.
    Nature. (2004) 430:218-22.
  • 9) Hemmi H, Takeuchi O, Sato S, Yamamoto M, Kaisho T, Sanjo H, Kawai T, Hoshino K, Takeda K, Akira S.
    The Roles of Two IκB Kinase-related Kinases in Lipopolysaccharide and Double Stranded RNA Signaling and Viral Infection.
    J Exp Med. (2004) 199:1641-50.
  • 8) Yamamoto M, Takeda K, Akira S.
    TIR domain-containing adaptors define the specificity of TLR signaling.
    Mol Immunol. (2004) 40:861-8.
  • 7) Yamamoto M, Sato S, Hemmi H, Uematsu S, Hoshino K, Kaisho T, Takeuchi O, Takeda K, Akira S.
    TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway.
    Nat Immunol. (2003) 4:1144-50.
  • 6) Sato S, Sugiyama M, Yamamoto M, Watanabe Y, Kawai T, Takeda K, Akira S.
    Toll/IL-1 Receptor Domain-Containing Adaptor Inducing IFN-β (TRIF) Associates with TNF Receptor-Associated Factor 6 and TANK-Binding Kinase 1, and Activates Two Distinct Transcription Factors, NF-κB and IFN-Regulatory Factor-3, in the Toll-Like Receptor Signaling.
    J Immunol. (2003) 171:4304-10.
  • 5) Kuwata H, Watanabe Y, Miyoshi H, Yamamoto M, Kaisho T, Takeda K, Akira S.
    IL-10-inducible Bcl-3 negatively regulates LPS-induced TNF-α production in macrophages.
    Blood. (2003) 102:4123-9.
  • 4) Yamamoto M, Sato S, Hemmi H, Hoshino K, Kaisho T, Sanjo H, Takeuchi O, Sugiyama M, Okabe M, Takeda K, Akira S.
    Role of Adaptor TRIF in the MyD88-Independent Toll-Like Receptor Signaling Pathway.
    Science. (2003) 301:640-3.
  • 3) Akira S, Yamamoto M, Takeda K.
    Role of adapters in Toll-like receptor signalling.
    Biochem Soc Trans. (2003) 31:637-42.
  • 2) Yamamoto M, Sato S, Mori K, Hoshino K, Takeuchi O, Takeda K, Akira S.
    Cutting Edge: A Novel Toll/IL-1 Receptor Domain-Containing Adapter That Preferentially Activates the IFN-β Promoter in the Toll-Like Receptor Signaling.
    J Immunol. (2002) 169:6668-72.
  • 1) Yamamoto M, Sato S, Hemmi H, Sanjo H, Uematsu S, Kaisho T, Hoshino K, Takeuchi O, Kobayashi M, Fujita T, Takeda K, Akira S.
    Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4.
    Nature. (2002) 420:324-329.