研究業績

Ⅰ. 代表的論文

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  • ㉛ Tachibana Y, Sasai M, Yamamoto M (Corresponding author).
    　CRISPR screens identify genes essential for in vivo virulence among proteins of hyperLOPIT-unassigned subcellular localization in Toxoplasma.
    　mBio (2024) e0172824. doi: 10.1128/mbio.01728-24. PMID: 39082802

  • ㉚ Ihara F, Kyan H, Takashima Y, Ono F, Hayashi K, Matsuo T, Igarashi M, Nishikawa Y, Hikosaka K, Sakamoto H, Nakamura S, Motooka D, Yamauchi K, Ichikawa-Seki M, Fukumoto S, Sasaki M, Ikadai H, Kusakisako K, Ohari Y, Yoshida A, Sasai M, Grigg ME, Yamamoto M (Corresponding author).  
         Far-East Asian Toxoplasma isolates share ancestry with North and South/Central American recombinant lineages.
    　 Nat Commun. (2024) 15:4278. doi: 10.1038/s41467-024-47625-6. PMID: 38778039

  • ㉙ Okamoto M, Sasai M, Kuratani A, Okuzaki D, Arai M, Wing JB, Sakaguchi S, Yamamoto M (Corresponding author).
         A genetic method specifically delineates Th1-type Treg cells and their roles in tumor immunity.
        Cell Rep. (2023) 42:112813. doi: 10.1016/j.celrep.2023.112813. PMID: 37440410

  • ㉘ Tachibana Y, Hashizaki E, Sasai M, Yamamoto M (Corresponding author).
         Host genetics highlights IFN-γ-dependent Toxoplasma genes encoding secreted and non-secreted virulence factors in in vivo CRISPR screens.
         Cell Rep. (2023) 42:e112592.     PMID: 37269286

  • ㉗ Hashizaki E, Sasai M, Okuzaki D, Nishi T, Kobayashi T, Iwanaga S, Yamamoto M (Corresponding author).
    　 Toxoplasma     IWS1 Determines Fitness in Interferon-γ-Activated Host Cells and Mice by Indirectly Regulating ROP18 mRNA Expression.
    　 mBio. (2023) Jan 30:e0325622. doi: 10.1128/mbio.03256-22. PMID: 36715543 

  • ㉖  Pradipta A, Sasai M, Motani K, Ma JS, Lee Y, Kosako H, Yamamoto M (Corresponding author).
    　Cell-autonomous Toxoplasma killing program requires Irgm2 but not its microbe vacuolar localization.
    　Life Sci Alliance. (2021) Jun 2;4(7):e202000960. doi:10.26508/lsa.202000960.  PMID: 34078740

  • ㉕ Sasai M, Ma JS, Okamoto M, Nishino K, Nagaoka H, Takashima E, Pradipta A, Lee Y, Kosako H, Suh PG, Yamamoto M (Corresponding author).
         Uncovering a novel role of PLCβ4 in selectively mediating TCR signaling in CD8+ but not CD4+ T cells.
         J Exp Med. (2021).     Jul 5;218(7):e20201763. doi: 10.1084/jem.20201763. PMID: 33970189

  • ㉔ Pradipta A, Bando H, Ma JS, Tanaka S, Sasai M, Yamamoto M (Corresponding author).
        Plasmodium UIS3 avoids host cell-autonomous exclusion that requires GABARAPs but not LC3 and autophagy.
        Parasitol Int. (2021) Mar 23;83:102335. doi: 10.1016/j.parint.2021.102335.      PMID: 33771680

  • ㉓ Sakaguchi N, Sasai M, Bando H, Lee Y, Pradipta A, Ma JS, Yamamoto M (Corresponding author).
        Role of Gate-16 and Gabarap in Prevention of Caspase-11-Dependent Excess Inflammation and Lethal Endotoxic Shock.
        Front Immunol. (2020) 11:561948. doi: 10.3389/fimmu.2020.561948. PMID: 33042141 

  • ㉒ Nishiyama S, Pradipta A, Ma JS, Sasai M, Yamamoto M (Corresponding author).
        T cell-derived interferon-γ is required for host defense to Toxoplasma gondii.　
        Parasitol Int. (2020) 75:102049. doi: 10.1016/j.parint.2019.102049.

  • ㉑ Lee Y, Yamada H, Pradipta A, Ma JS, Okamoto M, Nagaoka H, Takashima E, Standley DM, Sasai M, Takei K, Yamamoto M (Corresponding author).
        Initial phospholipid-dependent Irgb6 targeting to Toxoplasma gondii vacuoles mediates host defense.
        Life Sci. Alliance. (    2020) 3(1). doi: 10.26508/lsa.201900549.

  • ⑳ Bando H, Pradipta A, Iwanaga S, Okamoto T, Okuzaki D, Tanaka S, Vega-Rodríguez J, Lee Y, Ma JS, Sakaguchi N, Soga A, Fukumoto S, Sasai M, Matsuura Y, Yuda M, Jacobs-Lorena M, Yamamoto M (Corresponding author).

        CXCR4 regulates Plasmodium development in mouse and human hepatocytes.
        J Exp Med. 2019 Aug 5;216(8):1733-1748. doi: 10.1084/jem.20182227.

  • ⑲ Bando H, Lee Y, Sakaguchi N, Pradipta A, Sakamoto R, Tanaka S, Ma JS, Sasai M, Yamamoto M (Corresponding author).

        Toxoplasma Effector GRA15-Dependent Suppression of IFN-γ-Induced Antiparasitic Response in Human Neuron.
        Front Cell Infect Microbiol. 2019 May 1;9:140. doi: 10.3389/fcimb.2019.00140.

  • ⑱ Bando H, Lee Y, Sakaguchi N, Pradipta A, Ma JS, Tanaka S, Cai Y, Liu J, Shen J, Nishikawa Y, Sasai M, Yamamoto M (Corresponding author).
        Inducible Nitric Oxide Synthase Is a Key Host Factor for Toxoplasma GRA15-Dependent Disruption of the Gamma Interferon-Induced Antiparasitic Human Response.
        mBio. 2018 Oct 9;9(5). pii: e01738-18. doi: 10.1128/mBio.01738-18.
  • ⑰ Bando H, Sakaguchi N, Lee Y, Pradipta A, Ma JS, Tanaka S, Lai DH, Liu J, Lun ZR, Nishikawa Y, Sasai M, Yamamoto M (Corresponding author).
        Toxoplasma Effector TgIST Targets Host IDO1 to Antagonize the IFN-γ-Induced Anti-parasitic Response in Human Cells.
        Front Immunol. (2018) 9:2073. doi: 10.3389/fimmu.2018.02073.
  • ⑯ Sasai M, Sakaguchi N, Ma JS, Nakamura S, Kawabata T, Bando H, Lee Y, Saitoh T, Akira S, Iwasaki A, Standley DM, Yoshimori T, Yamamoto M (Corresponding author).
        Essential role for GABARAP autophagy proteins in interferon-inducible GTPase-mediated host defense.
        Nature Immunology. (2017) 18:899-910. doi: 10.1038/ni.3767.
  • ⑮ Lee Y, Sasai M, Ma J, Sakaguchi N, Ohshima J, Bando H, Saitoh T, Akira S, Yamamoto M (Corresponding author).
        p62 plays a specific role in interferon-γ-induced presentation of a Toxoplasma vacuolar antigen.
        Cell Rep. (2015) 13:223-233. doi: 10.1016/j.celrep.2015.09.005.
  • ⑭ Ohshima J, Sasai M, Liu J, Yamashita K, Ma JS, Lee Y, Bando H, Howard JC, Ebisu S, Hayashi M, Takeda K, Standley DM, Frickel EM, Yamamoto M (Corresponding author).
        RabGDIα is a negative regulator of interferon-γ-inducible GTPase-dependent cell-autonomous immunity to Toxoplasma gondii.
        Proc Natl Acad Sci U S A. (2015) 112:E4581-4590. doi: 10.1073/pnas.1510031112.
  • ⑬ Ma JS, Sasai M, Ohshima J, Lee Y, Bando H, Takeda K, Yamamoto M (Corresponding author).
        Selective and strain-specific NFAT4 activation by the Toxoplasma gondii polymorphic dense granule protein GRA6.
        J Exp Med. (2014) 211:2013-32. doi: 10.1084/jem.20131272.
  • ⑫ Ohshima J, Lee Y, Sasai M, Saitoh T, Ma JS, Kamiyama N, Matsuura Y, Pann-Ghill S, Hayashi M, Ebisu S, Takeda K, Akira S, Yamamoto M (Corresponding author).
        Role of the mouse and human autophagy proteins in IFN-γ-induced cell-autonomous responses against Toxoplasma gondii.
        J Immunol. (2014) 192: 3328-3335. doi: 10.4049/jimmunol.1302822.
  • ⑪ Yamamoto M, Okuyama M, Ma JS, Kimura T, Kamiyama N, Saiga H, Ohshima J, Sasai M, Kayama H, Okamoto T, Huang DS, Soldati-Favre D, Horie K, Takeda J, Takeda K.
        A cluster of interferon-γ-inducible p65 GTPases plays a critical role in host defense against Toxoplasma gondii.
        Immunity (2012) 37:302-313.
  • ⑩ Yamamoto M, Ma JS, Mueller C, Kamiyama N, Saiga H, Kubo E, Kimura T, Okamoto T, Okuyama M, Kayama H, Nagamune K, Takashima S, Matsuura Y, Soldati-Favre D, Takeda K.
    ATF6 is a host cellular target of the Toxoplasma gondii virulence factor ROP18.
    J Exp Med. (2011) 208:1533-1546.
    この研究論文が、掲載紙の表紙カバーに選出された。（Ⅷ.その他を参照のこと）
  • ⑨ Yamamoto M, Standley DM, Takashima S, Saiga H, Okuyama M, Kayama H, Kubo E, Ito H, Takaura M, Matsuda T, Soldati-Favre D, Takeda K.
    A single polymorphic amino acid on Toxoplasma gondii kinase ROP16 determines the direct and strain-specific activation of Stat3.
    J Exp Med. (2009) 206: 2747-2760.
  • ⑧ Yamamoto M, Uematsu S, Okamoto T, Matsuura Y, Sato S, Kumar H, Satoh T, Saitoh T, Takeda K, Ishii KJ, Takeuchi O, Kawai T, Akira S.
    Enhanced TLR-mediated NF-IL6 dependent gene expression by Trib1 deficiency.
    J Exp Med. (2007) 204:2233-9.
  • ⑦ Yamamoto M, Sato S, Saitoh T, Sakurai H, Uematsu S, Kawai T, Ishii KJ, Takeuchi O, Akira S.
    Cutting Edge: Pivotal Function of Ubc13 in Thymocyte TCR Signaling.
    J Immunol. (2006) 177:7520-4.
  • ⑥ Yamamoto M, Okamoto T, Takeda K, Sato S, Sanjo H, Uematsu S, Saitoh T, Yamamoto N, Sakurai H, Ishii KJ, Yamaoka S, Kawai T, Matsuura Y, Takeuchi O, Akira S.
    Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling.
    Nat Immunol. (2006) 7:962-70.
  • ⑤ Yamamoto M, Yamazaki S, Uematsu S, Sato S, Hemmi H, Hoshino K, Kaisho T, Kuwata H, Takeuchi O, Takeshige K, Saitoh T, Yamaoka S, Yamamoto N, Yamamoto S, Muta T, Takeda K, Akira S.
    Regulation of Toll/IL-1-receptor-mediated gene expression by the inducible nuclear protein IκBζ.
    Nature. (2004) 430:218-22.
  • ④ Yamamoto M, Sato S, Hemmi H, Uematsu S, Hoshino K, Kaisho T, Takeuchi O, Takeda K, Akira S.
    TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway.
    Nat Immunol. (2003) 4:1144-50.
  • ③ Yamamoto M, Sato S, Hemmi H, Hoshino K, Kaisho T, Sanjo H, Takeuchi O, Sugiyama M, Okabe M, Takeda K, Akira S.
    Role of Adaptor TRIF in the MyD88-Independent Toll-Like Receptor Signaling Pathway.
    Science. (2003) 301:640-3.
  • ② Yamamoto M, Sato S, Mori K, Hoshino K, Takeuchi O, Takeda K, Akira S.
    Cutting Edge: A Novel Toll/IL-1 Receptor Domain-Containing Adapter That Preferentially Activates the IFN- Promoter in the Toll-Like Receptor Signaling.
    J Immunol. (2002) 169:6668-72.
  • ① Yamamoto M, Sato S, Hemmi H, Sanjo H, Uematsu S, Kaisho T, Hoshino K, Takeuchi O, Kobayashi M, Fujita T, Takeda K, Akira S.
    Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4.
    Nature. (2002) 420:324-329.